Aceva Active-D Plus Bottle
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Active-D Plus

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Active-D Plus Provides Vitamin D And The Necessary Cofactors For High Bioavailability

Vitamin D has a widespread effect on the human body. Vitamin D is important for optimal cardiovascular, neuromuscular and immune function and can be a factor in many symptoms people suffer from on a daily basis such as fatigue and general aches and pains.

Studies have shown that people with a Vitamin D level below 30 nmol/l have decreased strength and muscle wasting. One of the reasons for reduced muscle function is because people with deficient levels of Vitamin D are likely to have fatty muscles. In a recently published cross-sectional study, 59% of young women aged 16-22 in California (one of the sunniest states in the U.S.) had insufficient (< 29 ng/ml) levels of Vitamin D and 24% were deficient (< 20 ng/ml). Fat infiltration in muscle tissue affects strength and power and can impair physical functioning.1

Additional studies suggest that higher intake of vitamin D is associated with the reduced risk of certain cancers.2

People who have a high risk for deficiency include:

  • Those with limited sun exposure (most people in winter months)

  • People indoors most of the day

  • Obese individuals

  • Pregnant women

  • Dark skin individuals

Active-D contains the unique combination of Vitamin D and K-2. Studies have shown a slower progression of calcification in tissue for those taking both vitamin K2 and vitamin D together verse those just taking Vitamin D. The combination appears to protect against cardiovascular calcification. K2 appears to also help direct calcium to your skeleton, therefore preventing it from being deposited where you don't want it, such as your organs, joint spaces and arteries.

Deficiency of Vitamin D is becoming a well known epidemic due to the lack of daily sun exposure people receive on a daily basis. It is estimated that millions of Americans currently suffer from Vitamin D deficiency.

Technically not a "vitamin," vitamin D is in a class by itself. Its metabolic product, calcitrol, targets over 2000 genes (about 10% of the human genome) in the human body. Current research has implicated vitamin D deficiency as a major factor in the pathology of at least 17 varieties of cancer as well as heart disease, stroke, hypertension, autoimmune diseases, diabetes, depression, chronic pain, osteoarthritis, osteoporosis, muscle weakness, muscle wasting, birth defects, periodontal disease, and more.*

Vitamin D's influence on key biological functions vital to one's health and well-being mandates that vitamin D no longer be ignored by the healthcare industry nor by individuals striving to achieve and maintain a greater state of health.*

How To Get Enough Vitamin D

There are 3 ways for adults to insure adequate levels of vitamin D:

1. Regularly receive midday sun exposure in the late spring, summer, and early fall, exposing as much of the skin as possible.

2. Regularly use a sunbed (avoiding sunburn) during the colder months.

3. Take 5,000 IU per day for three months, then obtain a 25-hydroxyvitamin D test. Adjust your dosage so that blood levels are between 50–80 ng/mL (or 125–200 nM/L) year-round.




  1. Vicente Gilsanz, Arye Kremer, Ashley O. Mo, Tishya A. L. Wren, and Richard Kremer. Vitamin D Status and Its Relation to Muscle Mass and Muscle Fat in Young Women. J Clin Endocrinol Metab. 2010 Apr; 95(4): 1595–1601.

  2. Garland CF, Garland FC, Gorham ED, et al. The Role of Vitamin D in Cancer Prevention. American Journal of Public Health. 2006;96(2):252-261. doi:10.2105/AJPH.2004.045260.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

WARNING:  Consuming this product can expose you to chemicals including lead, which is known to the State of California to cause birth defects or other reproductive harm.  For more information go to



Serving Size: 1 capsule


Servings per Container: 120





% Daily Value





Vitamin A (as Beta Carotene)




Vitamin D (as Cholecalciferol)






Vitamin K (as Menaquinone-7)     100



Magnesium (as Magnesium Citrate)




Zinc (as Zinc Methionine)



Boron (as Boron Citrate)




* Daily Value not established

Other Ingredients: Gelatin (Capsule), Microcrystalline cellulose, Dicalcium Phosphate, L-Leucine, Silicon Dioxide


WARNING: All forms of Vitamin K may interact with blood thinning medications. If you are taking such medicines please consult your physician before taking this product.






Suggested Use:

As a dietary supplement, take one (1) capsule daily with food or as recommended by your health care professional. 


As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing, anticipate surgery, take any medication (especially blood thinning medications, as all forms of vitamin K are thought to interact with blood thinning medications) or are otherwise under medical supervision. 

Formulated to Be Free of Allergens Derived From: 

Wheat, soy, dairy, eggs, fish, crustacean shellfish, tree nuts, peanuts, artificial preservatives, sweeteners, color and flavors. 


* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 

References and Research Abstracts Supporting Active D Plus

1. Philippe Autier, MD; Sara Gandini, PhD. Vitamin D Supplementation and Total Mortality A Meta-analysis of Randomized Controlled Trials. Arch Intern Med. 2007;167(16):1730-1737

2. Vogelsang H, Ferenci P, Resch H, et al. Prevention of bone mineral loss in patients with Crohn’s disease by long-term oral vitamin D supplementation. Eur J Gastroenterol Hepatol 1995;7:609-14.

3. Lee P, Chen R. Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain. Arch Intern Med 2008;168:771-2.

4. Camargo CA Jr, Ganmaa D, Frazier AL, et al. Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia. Pediatrics 2012;130:e561-e567.

5. Lansdowne ATG, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter.Psychopharmacology 1998;135:319-23.

6. Boucher BJ. Inadequate vitamin D status: does it contribute to the disorders comprising syndrome ‘X’? Br J Nutr1998;79:315-27 [review].

7. Borissova AM, Tankova T, Kirilov G, et al. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract 2003;57:258-61.

8. Nikooyeh B, Neyestani TR, Farvid M, et al. Daily consumption of vitamin D- or vitamin D + calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial. Am J Clin Nutr2011;93764-71.)

9. S. Bobo Tanner and Susan A. Harwell. More than healthy bones: a review of vitamin D in muscle health. Ther Adv Musculoskel Dis 2015, Vol. 7(4) 152–159